ABSTRACT
Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.
Subject(s)
Animals , Ascorbic Acid/analysis , Cataract/metabolism , Crystallins/analysis , Disease Models, Animal , Endotoxins , Escherichia coli , Lens, Crystalline/metabolism , Lipopolysaccharides , RabbitsABSTRACT
The synergistic effects of protein deficiency and U-V radiation is cataractogenic as seen in our experimental model though individually these had no damaging effect on enzymatic profile and clinical appearance.